Can a \u201ccertain\u201d enzyme be the key to extending the human lifespan? <\/p>\n\n\n\n
Some of the latest research on antiaging and longevity seems to point to a specific enzyme known as \u201cSirt6,\u201d which could hold the key to a greater understanding of why humans age and provide an avenue for the development of some remarkably effective antiaging therapies.\u00a0<\/p>\n\n\n\n
In all mammals, there are seven different enzymes known as sirtuins, called Sirt1 through to Sirt7, but it is Sirt6 that is making the news among anti-aging circles. Sirt6 is a protein involved in regulating chromatin, the complex of DNA and protein found in our cells, and it has also been shown to play a role in metabolism, disease \u2013 and aging. Sirt6 is vital for repairing DNA damage \u2013 the kind of damage that leads to genomic instability and ultimately contributes to aging. The ability for Sirt6 to repair DNA damage wains with age. But studies have shown that supplementation with Sirt6 boosts DNA repair once again, so it is no surprise that this remarkable enzyme has been dubbed the \u201clongevity sirtuin.\u201d<\/p>\n\n\n\n
Last year, Bar-Ilan University researchers were able to not only increase the life expectancy in mice with Sirt6 but use it to enable old mice to conduct the same level of vigorous activity as their young counterparts without becoming frail.<\/p>\n\n\n\n
\u201cThis discovery, combined with our previous findings, shows that Sirt6 controls the rate of healthy aging,\u201d said Professor Cohen of Bar-Ilan University\u2019s Mina and Everard Goodman Faculty of Life Sciences. \u201cIf we can determine how to activate it in humans, we will be able to prolong life, and this could have enormous health and economic implications.\u201d<\/p>\n\n\n\n
Before that, back in 2019, Vera Gorbunova, professor of biology at the University of Rochester, and her team demonstrated that an overexpression of Sirt6 protein leads to extended lifespan and also that the opposite is true \u2013 a deficiency can cause premature aging.<\/p>\n\n\n\n
It has also been found that centenarians have an over-abundance of naturally occurring Sirt6.<\/p>\n\n\n\n
These facts and findings are being leveraged for gene therapies designed to halt or slow the aging process by Genflow Biosciences, which earlier this year became Europe\u2019s first publicly traded longevity biotech.<\/p>\n\n\n\n
Although research has shown that overexpressing Sirt6 extends lifespan, the actual underlying cellular mechanisms still need unpicking; now a new paper, co-authored by Vera Gorbunova, which looks at Sirt6 function in fruit flys and examines its role in regulating longevity has provided insight into the mechanisms by which overexpression Sirt6 leads to a longer lifespan.<\/p>\n\n\n\n
The researchers concluded that overexpressing Sirt6 \u201cmay extend lifespan and healthspan in flies via increased oxidative stress resistance and\/or reduced protein synthesis.\u201d Sirt6 increases lifespan, in part, by opposing the activity of Myc, a master regulator of protein synthesis, which is associated with decreased protein synthesis.\u201d<\/p>\n\n\n\n
<\/p>\n","protected":false},"excerpt":{"rendered":"
Can a \u201ccertain\u201d enzyme be the key to extending the human lifespan? Some of the latest research on antiaging and longevity seems to point to a specific enzyme known as \u201cSirt6,\u201d which could hold the key to a greater understanding of why humans age and provide an avenue for the development of some remarkably effective antiaging therapies.\u00a0 In all mammals, there are seven different enzymes known as sirtuins, called Sirt1 through to Sirt7, but it is Sirt6 that is making […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-333","post","type-post","status-publish","format-standard","hentry","category-anti-aging"],"_links":{"self":[{"href":"https:\/\/healthnews.zone\/index.php?rest_route=\/wp\/v2\/posts\/333","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healthnews.zone\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthnews.zone\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthnews.zone\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/healthnews.zone\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=333"}],"version-history":[{"count":1,"href":"https:\/\/healthnews.zone\/index.php?rest_route=\/wp\/v2\/posts\/333\/revisions"}],"predecessor-version":[{"id":334,"href":"https:\/\/healthnews.zone\/index.php?rest_route=\/wp\/v2\/posts\/333\/revisions\/334"}],"wp:attachment":[{"href":"https:\/\/healthnews.zone\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=333"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthnews.zone\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=333"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthnews.zone\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=333"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}